QCM systems & Sensors
High accuracy QCM systems “NAPiCOS” - Biomolecule interaction Analyzers-
“NAPiCOS” is QCM (*) technology based analyzer for biological molecular interaction, with which differential measurement by QCM twin sensor is available. The system enables users to make high sensitivity measurements for molecular interaction such as biological protein binding, DNA binding and so on with just simple injection of sample. Additionally, NAPiCOS system can be used for gas measurement in materials developments and environmental monitoring fields. NAPiCOS series consist of two types, manual operation type”NAPiCOS system” and Automatic operation type “NAPiCOS Auto.”We at NDK will contribute to establish safe & untroubled living conditions through quantification and analysis of specific substance in biochemistry, clinical, environment and food chemistry fields etc.
◊NAPiCOS is a coined word created by NDK, combining the words “nano,” “pico” and “sensor.”A possibility of trace amount measurement with nano and pico level is infused into the word NAPiCOS as a new measurement technology proposed by high technology crystal products manufacturer NDK.”
(*) QCM : Shortened words of Quartz Crystal Microbalance. Molecular level measurement method using quartz crystal as sensor board.
| Product name | Outward forms |
|---|---|
| NAPiCOS system
Click here to find out more and to watch the product promotion video. |
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| NAPiCOS Auto
Click here to find out more and to watch the product promotion video. |
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Application examples
Almost measurement applications with NAPiCOS such as immune reaction and others can be applied. The followings are several examples of the measurement ones, which can be available as reference NAPiCOS series can be used for other applications that are not described in this site too.
If you have any questions, please feel free to contact us.
♦ Protein
◊ Measurement of label free immune response of the acute phase protein CRP (C reactive protein)
◊ Immuno-measurement of low-concentration insulin (100pg/mL to 20ng/mL)
◊ Measurement of allergen contained in food extract
◊ Quantification sensor for concentration of antibody drugs
♦ Peptide
◊ Evaluation of Peptide's property of binding to PMMA stereo- complex membrane
♦ Glycan
◊ Calculation of the dissociation constant of glycoprotein
♦ Nucleic acid
◊ Double-strand DNA formation & Protein binding
◊ Binding transcriptional factor to DNA
♦ Substance with low molecular weight
◊ Measurement of low-molecular substance
♦ Immobilization protocol
◊ For immobilization with carboxyl radical, Amino radical, and others on the surface of the sensor, please contact us.
NAPiCOS Technologies
♦ Features of NAPiCOS technologies
Measurement method of NAPiCOS,
relational expressions between mass and frequency, and cautions of measurement method
♦ Comparison between NAPiCOS and SPR (Surface Plasmon Resonance method)
QCM twin sensors
QCM twin sensors for NAPiCOS series 
| Model | Nominal Freq. (MHz) |
Blank Cut angle | Blankshape | Diameter of blank (mm) |
Holder | Electrode | Operating temperature range (°C) |
|
|---|---|---|---|---|---|---|---|---|
| Shape | Material | |||||||
| (Surface+ground) | ||||||||
| PSA-SB-3002T | 30 | AT cut | Circle plate | Φ8.7 | FR-4 | Twin | Au+Cr | +5 to +50 |
| PSA-SE-3002T (*) | 30 | AT cut | Circle plate | Φ14 | FR-4 | Twin | Au+Cr | +5 to +50 |
(*) For Micro fluidic chip
* Specifications and product names described in this site are subject to change for improvement without notice. The products are subject to production stoppage without notice
Other QCM sensors
 Single electrode QCM sensor (Lead type) |
 Single electrode QCM sensor (FR-4 type) |
| Model | Nominal Freq. (MHz) |
Blank Cut angle | Blankshape | Diameter of blank (mm) |
Holder | Electrode | Operating temperature range (°C) |
|
|---|---|---|---|---|---|---|---|---|
| Shape | Material *1 | |||||||
| (Surface+ground) | ||||||||
| PSA-SL-0901T | 9 | AT cut | Circle plate | Φ8.7 | Lead type | Single | Au+Cr | +5 to +85 |
| PSA-SB-0901T | 9 | AT cut | Circle plate | Φ8.7 | FR-4 | Single | Au+Cr | +5 to +50 |
| PSA-SL-3001T | 30 | AT cut | Circle plate | Φ8.7 | Lead type | Single | Au+Cr | +5 to +85 |
| PSA-SB-3001T | 30 | AT cut | Circle plate | Φ8.7 | FR-4 | Single | Au+Cr | +5 to +50 |
*1:Besides the above electrode materials , Ag + Al (for surface) and NiCr + Ti (for ground) are available.
·Besides the QCM twin sensors for NAPiCOS series, we offer conventional QCM sensors with single electrode.
·The products described in the above are our standard ones. Besides them, we also offer QCM sensors with lead type and nominal frequency range from 5 to 50MHz and the other ones with Φ5mm diameter blank.
·Custom- made QCM sensors can be discussed. Please contact us through NAPiCOS sales.
* Specifications and product names described in this site are subject to change for improvement without notice. The products are subject to production stoppage without notice
Contact us
For more details of NAPiCOS, please contact us though the following means.
♦ NAPiCOS sales contact
◊ TEL : +81-3-5453-6736
◊ FAX : +81-3-5453-6822
◊ E-Mail : bio-m@ndk.com