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NAPiCOS Auto（PSA20A）
Features
Enable users to make automatic measurement of molecular interaction (immune reaction etc.) with simple sample injection!
Micro amount sample measurement possible with microfluidic chip newly developed (Flow cell capacity 5 μL)!
Differential measurement by negative control on a sensor possible with world first QCM twin sensor!
- Real time molecular interaction analysis with high sensitivity and high stability.
Approx. 15 minutes from antibody immobilization to antigen measurement - High sensitivity 30MHz QCM twin sensor with two electrodes made from high quality grade synthetic quartz crystal (world first)
(Sensitivity : A approx.10ng/mL in antigen - antibody reaction of IgG) - Flow injection measurement system adopted &real time monitoring from antibody immobilization to antigen-antibody reaction.
Flow injection analysis method principle JIS K0126 compliant - High precision analyzer
Immediate frequency measurement by high speed signal processing
High stability oscillation in liquid phase by low noise oscillation unit
Reduction of influence caused by temperature change etc. using differential measurement with twin oscillation circuit - Automatic programming
Automatic measurement with simple setting of immune measurement protocol - Analysis application software
Corresponding to Kinetics analysis, affinity analysis and calibration line analysis etc. - Microfluidic chip
Corresponding to high sensitivity measurement with micro amount sample using microfluidic Chip (Flow cell capacity : approx. 5 μL)
Standard Specifications
| Product Name | Model | Specifications |
|---|---|---|
| Analyzer | PSA20A |
Voltage：AC100 to 240V 50Hz/60Hz Frequency measurement resolution：0.01Hz Power consumption：100VA or less USB interface：USB2.0 compliant Flow cell capacity：50μL(When microfluidic chip used：5 μL) Dimensions：W530×H325×D410mm |
| Software (Pre-installed in an accouterment PC) |
- |
・Automatic operation software (NAPiCOS 20A Auto Operation) ・Analysis software (NAPiCOS Analysis) Kinetics analysis, affinity analysis, Standard curve etc. analysis |
| QCM twin sensor | PSA-SB-3002W | 30MHz twin sensor |
| PSA-SE-3002T | 30MHz twin sensor (Dedicated for microfluidic chip) |
External Appearance of Product
(1) Analyzer
Overview of analyzer
Auto-loading function
Sample injection
(2) Automatic control programming / Application software
Automatic operation screen
Affinity analysis screen
Calibration line analysis screen
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Measurement Example
■Sample conditions
- Solution sending：0.01M PBS pH7.2
- Antibody：Anti-CRP 100μg/mL
- Blocking：0.1% BSA
- Antigen：CRP 10μg/mL
■Electrode membrane of QCM twin senor
- Reference electrode 0.1%BSA Blocking
- Reaction electrode Anti-CRP, 0.1%BSA Blocking
■Measurement conditions
- 30MHz QCM twin sensor, Flow rate 50μL/min
- Flow cell volume 50μL
- Injection volume 100μL
Real time monitoring antigen-antibody reaction
Measurement Result
- Black：Reference electrode
- Red：Reaction electrode
- Blue：Differential value=Reaction electrode reaction-Reference electrode reaction
- Note：When reaction amount of reference electrode is small, reaction electrode waveform and differential one are seen as piled lines
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Frequency Stability
Owing to high sensitivity QCM twin sensor and low phase noise circuit technology, frequency stability in liquid phase is more improved comparing to past ones. Short-term stability of 30MHz QCM twin sensor achieves 0.01×10-6 or less, and high stability and high sensitivity can be achieved.
Stable waveform
Short term frequency stability